Astilbin ameliorates intestinal inflammation and suppresses colorectal cancer cell proliferation by regulating NLRP3 inflammasome and nuclear factor-kappa B signaling pathway
AST inhibited colorectal carcinoma growth by blocking the expression of NLRP3 and NF-κB and inducing an apoptotic cascade and suppressing iNOS-COX2 and IL-1β as regulators of inflammation and growth signal. This study advocates the application of phytopharmaceutical supplements for the management of colorectal carcinoma.
Authors
- Jinqing Hui
- Y Li
- Xiao Zhong Deng
- Lu Han
Institutions
- Shanxi Medical University (CN)
- Shaanxi Provincial People's Hospital (CN)
- Beijing Aerospace General Hospital (CN)
- Songjiang District Central Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
- First Hospital of Xi'an (CN)
Publication Details
- Journal
- Indian Journal of Pharmacology
- Published
- 2026-01-01
- DOI
- https://doi.org/10.4103/ijp.ijp_678_24
- Primary Topic
- Phytochemical Studies and Bioactivities
- Type
- article
- Field-Weighted Citation Impact
- 0.00