SiO2/Fe3O4 as a recyclable catalyst employing for the preparation of oxazinoazepines via multicomponent reaction of isatoic anhydrides

This work investigated the use of a complex technique including 4-imino-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one, α-haloketones, electron-deficient acetylenic compounds and isocyanates in a water-based solution at normal room temperature in the presence of SiO2/Fe3O4@Graphene Oxide. The goal was to generate novel thiazinoazepine molecules with significant yields. The oxazinoazepines that have been synthesized contain NH functional groups with acidic protons and demonstrate notable antioxidant activity. The used technology for synthesizing oxazinoazepines provides several advantages, including rapid reaction kinetics, outstanding product yield, and straightforward product isolation.