Ag/Fe3O4/ZnO MNCs nanoparticles promoted synthesis of pyrazoloazepines using isatin multicomponent reactions

In this research new derivatives of pyrazoloazepines were synthesized in high yields using multi-component reaction of isatin, alkyl bromides, activated acetylenic compounds and hydrazine in the presence of Ag/Fe3O4/ZnO magnetic nanocomposite (MNCs) as a high-performance magnetic catalyst in ionic liquid at room temperature. The Ag/Fe3O4/ZnO magnetic nanocomposits (MNCs) were synthesized using deionized water. Also, the catalytic activity of the Ag/Fe3O4/ZnO MNCs was evaluated in reduction of organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions. The results indicated that the biosynthesized nanocomposite (NCs) have high catalytic activity for organic pollutants within few seconds. Short time of reaction, high yields of product, easy separation of catalyst and products are some advantages of this procedure.