Targeting matrix metalloproteinase-14 disrupts DNA repair and reduces viability in adrenocortical carcinoma
These findings reveal a novel nuclear function for MMP-14 in DNA repair and identify MMP-14 as a promising therapeutic target in ACC. Targeting MMP-14 may sensitize ACC tumors to DNA-damaging chemotherapy by impairing the repair of therapy-induced lesions.
Authors
- Shivam Priya
- Barbara Bedogni (ORCID: https://orcid.org/0000-0002-1539-9064)
- Changxian Shen (ORCID: https://orcid.org/0000-0002-7668-7166)
- Haichang Li (ORCID: https://orcid.org/0000-0001-9784-6480)
- Priya H. Dedhia (ORCID: https://orcid.org/0000-0002-1884-408X)
- Liudmila V. Popova (ORCID: https://orcid.org/0000-0003-4209-8520)
- Barbra S. Miller (ORCID: https://orcid.org/0000-0002-2533-7940)
- Daniel M. Chopyk (ORCID: https://orcid.org/0000-0003-4207-1360)
- John E. Phay (ORCID: https://orcid.org/0000-0002-8482-2137)
- Lindsey Hartshorn
- Yaoling Shu
- Caleb Araujo
- Varsha Thakur
- Zhongguang Li
Institutions
- University of Arizona (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Cancer Genetics (United States) (US)
- Sylvester Comprehensive Cancer Center (US)
- Arizona Oncology (US)
- The Ohio State University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-07
- DOI
- https://doi.org/10.64898/2026.01.06.697992
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Ohio Cancer Research
- Pelotonia
- National Institutes of Health
- National Cancer Institute
- DOD Peer Reviewed Cancer Research Program