Cover Feature: From Structure to Function: Development of Relaxin‐3 Analogs and their Role in RXFP3 Signaling (ChemBioChem 1/2026)

The RXFP3/Relaxin-3 system is implicated in behaviors such as addiction, anxiety and depression, making it an attractive pharmaceutical target. Because RXFP3 is primarily located in the central nervous system, achieving blood–brain barrier penetration is crucial. The cover depicts the relaxin family peptide receptor 3 and its ligand relaxin-3 in the bottom left corner, with key reported small molecules shown in white. The alpha helix in the background represents recently developed single-chain peptidomimetics. More details can be found in the Research Article by Mohammed Akhter Hossain and co-workers (DOI: 10.1002/cbic.202500664).