Modulating rheology and bioactivity in dermal fillers: the emerging role of platelet-rich plasma (PRP)

This review explores the concept of dilutional rheomodulation in dermal fillers with the addition of platelet-rich plasma (PRP) and its potential to improve both aesthetic and regenerative outcomes. PRP is a biological product rich in growth factors and cytokines derived from the patient's own blood, which plays a significant role in tissue regeneration and healing. According to previous studies that utilized titrated aqueous solutions as solvents, it is hypothesized that incorporating PRP into different dermal filler formulations may be effective for modulating the rheological parameteres of dermal fillers while providing regenerative and immunomodulatory properties, potentially improving biocompatibility, injectability, distribution, and overall tissue integration as suggested by preliminary investigations. This combined approach may reduce severe adverse effects associated with filler injections while enhancing their biostimulatory effects. Moreover, PRP has been shown to stimulate collagen production and promote skin regeneration, which may extend the filler's longevity and improve skin texture and elasticity. Although early studies suggest positive outcomes, further clinical trials are needed to determine optimal dilution ratios, establish best practices, and assess long-term safety and efficacy. This review highlights the promising potential of PRP-filler combinations in advancing aesthetic procedures through the integration of immediate volumization with regenerative skin enhancement.