Palladium‐Catalyzed Dihalogenative Cyclization of Amide‐Fused 1,6‐Enynes for the Synthesis of Lactams

Owing to their unique properties, the synthesis of α ‐methylenelactams has long been a research hotspot in synthetic chemistry. In this article, a Pd‐catalyzed intramolecular dihalogenative cyclization reaction of amide‐fused 1,6‐enynes was developed, which successfully afforded a series of α ‐methylenelactam compounds. This reaction exhibits advantages including good yields, excellent stereoselectivity, and favorable functional group tolerance. In addition, the synthetic application of the products showed that the halogens reserved in the products can further undergo reactions such as cross‐coupling reactions and substitution reactions.