m-EASIX (better than EASIX) predicts severe CAR T-cell toxicities, worse overall survival, and discriminates cytokine release syndrome from sepsis
m-EASIX is a practical and accessible tool for the early prediction of severe CAR T-cell-related toxicities, risk stratification, and differential diagnosis from sepsis, offering potential to guide clinical decision-making and early intervention.
Authors
- Valentin Ortiz-Maldonado
- P. Gómez‐Ramírez
- O. Penack
- Manel Juan
- Mrs. María Queralt Salas
- Carlos Fernández de Larrea (ORCID: https://orcid.org/0000-0003-4930-9255)
- Helena Brillembourg
- Julia Martínez-Sánchez (ORCID: https://orcid.org/0000-0001-5934-7912)
- David F. Moreno (ORCID: https://orcid.org/0000-0002-1752-3081)
- A. Oliver-Caldés
- Adrián Téllez (ORCID: https://orcid.org/0000-0003-3502-5999)
- Francesc Fernández‐Avilés (ORCID: https://orcid.org/0000-0002-3733-590X)
- Helena Ventosa-Capell (ORCID: https://orcid.org/0000-0003-1913-5709)
- Blanca De Moner (ORCID: https://orcid.org/0009-0001-4500-3884)
- Julio C. Delgado (ORCID: https://orcid.org/0000-0002-3455-1711)
- Azucena E. González-Navarro
- Maribel Díaz-Ricart
- JM Nicolás
- Álvaro Urbano
- Sara Alonso Fernandez (ORCID: https://orcid.org/0009-0007-0018-8997)
- Gontzal Iraola
- Ana Belén Moreno-Castaño
- Marta Palomo
- Gines Escolar
- Pedro Castro (ORCID: https://orcid.org/0000-0002-6118-8970)
- Enric Carreras
- Patricia Molina
- Alex Ramos
- Nuria Martínez-Cibrián
Institutions
- Josep Carreras Leukaemia Research Institute (ES)
- Departament de Salut (ES)
- Hospital Clínic de Barcelona (ES)
- Institute for Research in Biomedicine (ES)
- FC Barcelona (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1664788
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 31.52
Funders
- “la Caixa” Foundation
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Instituto de Salud Carlos III