Pilot proteomic analysis of immune dysregulation in dengue with prior SARS-CoV-2 infection
Prior SARS-CoV-2 exposure may potentiate dengue severity via cross-reactive antibody-mediated immune modulation, skewing toward Th2 responses and enhancing viral replication. These findings suggest novel candidate biomarkers for stratifying the dengue risk in co-endemic regions. However, the study's exploratory nature, small cohort (n = 18), pooled proteomic methodology, and limited clinical characterization necessitate validation in larger longitudinal studies.
Authors
- Luis Román Ramírez-Palacios
- Juan Alpuche (ORCID: https://orcid.org/0000-0002-8532-6717)
- Diego Sait Cruz-Hernández (ORCID: https://orcid.org/0000-0003-4535-5262)
- Sergio Roberto Aguilar-Ruíz (ORCID: https://orcid.org/0000-0002-2412-0360)
- Elizabeth Cruz-Altamirano
- Miguel Angel Mayoral-Chávez
- Luz Maria Quirino-Vela
Institutions
- Instituto Tecnológico de Oaxaca (MX)
- Benito Juárez Autonomous University of Oaxaca (MX)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1696179
- Citations
- 1
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 41.85