Long Term Association of Ramadan Fasting and Renal Function in Patients with Chronic Kidney Disease

Background: Throughout Ramadan fasting (RF), muslims strictly avoid eating, drinking, and sexual intercourse together with other actions. This study aimed to determine the long-term association of RF with renal function and blood urea nitrogen (BUN) in patients with chronic kidney disease (CKD).Methods: In a cross-sectional study, 8725 individuals from Mashad Cohort Study were enrolled during a period of 10 years and followed through 3-year intervals to moderate the risk of losing contact. To asses renal function, glomerular filtration rate (GFR), BUN and creatinine were measured. RF was evaluated by a 16-item questionnaire. CKD was defined by National Kidney Foundation guideline as GFR<60 ml/ min/1.73 m2. Patients were categorized in three groups based on GFR of eGFR≥60, 60-89, and <15 mL/min per 1.73 m2.Results: The mean age was 57.4 years and 48.1% were female. There was no significant relationship between RF and GFR, but a significant relationship was observed between fasting in other months and GFR. Loss of consciousness and severe hypoglycemia were higher among those with a GFR<45. Fasting during life, RF and in months other than Ramadan was accompanied by an increase in creatinine. Age was also associated with a significant rise in creatinine and BUN levels.Conclusion: This study suggests that patients with stable mild/moderate CKD may be allowed to fast if they are carefully monitored for their health status.