Opposing fates: a bipolar cellular model for FMDV replication shaped by 12C6+heavy-ion mutagenesis
Our work demonstrates that <sup>12</sup>C<sup>6+</sup> heavy-ion mutagenesis can rewire the host immunity-metabolism-cell cycle axis to dictate infection outcomes, providing a powerful framework and cellular toolkit for developing high-yield vaccine substrates and novel antiviral strategies.
Authors
- Xun Liu (ORCID: https://orcid.org/0000-0003-1366-8926)
- Yajun Li (ORCID: https://orcid.org/0000-0001-7747-742X)
- Xiangdong Song
- Fanglan An
- Yan Cui
- Shiyu Tao
- Jianping Liang
Institutions
- Gansu Agricultural University (CN)
- Institute of Modern Physics (CN)
- Gansu Normal University for Nationalities (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fcimb.2025.1715061
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00