Immunogenicity Enhancement via Self-Assembled mi3 Nanoparticles Displaying ESAT-6 Antigen
Our findings demonstrate that the ESAT-6-mi3 nanoparticle vaccine markedly enhances both humoral and cellular immune responses, outperforming traditional subunit vaccine approaches. This strategy shows strong potential as a next-generation booster vaccine to complement BCG and improve TB immunization outcomes.
Authors
- Zhi‐Gang Qian (ORCID: https://orcid.org/0000-0002-0133-0605)
- Yanmei Hao (ORCID: https://orcid.org/0009-0007-0448-6641)
- Sihang Dong
- X Wang
- Shuang Wu (ORCID: https://orcid.org/0000-0001-7618-5476)
- Heng Zhang (ORCID: https://orcid.org/0000-0002-0103-2173)
- Hongtao Wang (ORCID: https://orcid.org/0000-0003-1720-7828)
- Tao Xu (ORCID: https://orcid.org/0009-0003-1170-5145)
- Fangzheng Guo
- Yamin Song
- Ke Liang
Institutions
- Bengbu Medical College (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/ijn.s558312
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00