Global, regional, and national burden of influenza-associated lower respiratory infections, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021

Influenza-associated LRIs remain a significant global health challenge, particularly in low-income and high-risk populations. While global trends indicate progress, regional disparities and the impact of demographic factors highlight the need for tailored interventions. Targeted strategies-including equitable vaccine access, healthcare system strengthening, and integrated surveillance-are critical to mitigating burden in high-risk regions and populations.