Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics
Fibroblasts drive glioma recurrence, with AEBP1, ZNF708, and TSHZ2 predicting recurrence and chemoresistance. These genes promote immune suppression (via plasma cells) and activate recurrence pathways. Oligodendrocyte-astrocyte interactions shape the recurrent microenvironment, suggesting new therapeutic targets.
Authors
- Jinyan Luo
- Yuchen Zhu (ORCID: https://orcid.org/0000-0001-5148-8569)
- Lei Qiu (ORCID: https://orcid.org/0000-0002-0202-4618)
- Yuandong Cao (ORCID: https://orcid.org/0000-0002-9905-7941)
- W. Xu (ORCID: https://orcid.org/0000-0002-6690-2651)
- Ke Shi (ORCID: https://orcid.org/0000-0002-4814-1414)
- Gefei Jiang
- Xuelin Sun (ORCID: https://orcid.org/0000-0002-5483-2887)
- Jiaxuan Ding (ORCID: https://orcid.org/0000-0002-0127-8982)
- Yinjiao Fei
- Shu Zhou
Institutions
- Sun Yat-sen University (CN)
- Beijing Tian Tan Hospital (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1002/acn3.70306
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00