Investigation of Potent Anti-Mycobacterium tuberculosis Agents Derived from Pyridine Derivatives Targeting the Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Computational Analysis
Derivative <b>6</b> was the most potent compound (MIC: 0.5 μg mL<sup>-1</sup>), inhibiting intracellular bacteria, disrupting biofilms, and potently targeting InhA (IC<sub>5</sub> <sub>0</sub>: 0.36 μM). Its pyridine-thiazole scaffold was key for stable binding, as shown by molecular modeling.
Authors
- Malwina Kawka (ORCID: https://orcid.org/0000-0003-2469-6260)
- Bozena R. Dziadek (ORCID: https://orcid.org/0000-0002-4942-7385)
- Ahmed M. Atwa (ORCID: https://orcid.org/0000-0001-8580-4179)
- Abdelsamed I. Elshamy (ORCID: https://orcid.org/0000-0003-3302-3623)
- Mohamed G. Thabit (ORCID: https://orcid.org/0000-0002-2360-294X)
- Jarosław Dziadek (ORCID: https://orcid.org/0000-0003-1427-884X)
- Asmaa F. Kassem (ORCID: https://orcid.org/0000-0001-9020-9956)
- Ahmed Sabt (ORCID: https://orcid.org/0000-0001-6976-0196)
- Anna M. Brzostek (ORCID: https://orcid.org/0000-0002-7335-9853)
- Nguyễn Thị Thu Hà (ORCID: https://orcid.org/0000-0003-0975-4055)
- Małgorzata Korycka-Machala
- Ninh The Son
Institutions
- Prince Sattam Bin Abdulaziz University (SA)
- Pharos University in Alexandria (EG)
- Thi Qar University (IQ)
- Iraqi University (IQ)
- University of Łódź (PL)
- Institute for Medical Biology (PL)
- National Research Centre (EG)
- Egyptian Russian University (EG)
- Vietnam Academy of Science and Technology (VN)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/dddt.s566020
- Primary Topic
- Antimicrobial agents and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Narodowym Centrum Nauki