Respiratory Syncytial Virus–Mediated Gas6/Axl Axis Induces Hyporesponsive Macrophages to Promote Pneumococcal Proliferation in the Nasopharynx
Our findings reveal that the RSV infection-induced Gas6/Axl axis facilitates pneumococcal overgrowth by modulating macrophage function. Targeting the RSV-induced Gas6/Axl axis or modulating macrophage polarization may offer novel therapeutic strategies for preventing or managing severe pneumococcal infections exacerbated by viral pathogens such as RSV.
Authors
- Shigeki NAKAMURA
- Toshihiro Ito (ORCID: https://orcid.org/0000-0003-1728-2449)
- Yuzu Fukui
- Rumi Ueha (ORCID: https://orcid.org/0000-0002-0608-7237)
- Takehiko Shibata (ORCID: https://orcid.org/0000-0001-6475-9524)
- Nanami OKADA
- Saki Ishikawa
Institutions
- Tokyo Medical University (JP)
- University of Tokyo Hospital (JP)
- Nara Medical University Hospital (JP)
- Nara Medical University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1093/infdis/jiag004
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00