Empagliflozin protects against doxorubicin-induced arrhythmia by AMPK/mTOR-mediated autophagy in cardiomyocyte
Our research demonstrated for the first time that EMPA reduced the incidence of ventricular arrhythmia by regulating AMPK/mTOR signaling and restored autophagic flux in DOX-treated rats and NRVCMs.
Authors
- Chang Dai (ORCID: https://orcid.org/0000-0001-7971-883X)
- Yan Chen (ORCID: https://orcid.org/0000-0001-9311-6077)
- Yidong Lv
- Shulin Wu (ORCID: https://orcid.org/0000-0001-8276-7974)
- Chun-yu Deng
- Hui Yang
- Meng-zhen Zhang
- Hui-yi Liu
- Yu-mei Xue
- Hai-yan Zeng
- Fang Rao
Institutions
- Guangdong Academy of Medical Sciences (CN)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1016/j.ejphar.2026.178520
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00