Modulation of IRAK4 as a therapeutic strategy against monosodium urate- and xanthine-induced inflammation in macrophages and HepG2 cells
These findings demonstrate the dual anti-inflammatory effect of IRAK4 inhibition in both immune and hepatic cells and suggest a promising strategy to mitigate inflammation in gout.
Authors
- Mark Maienschein‐Cline
- Sriram Ravindran (ORCID: https://orcid.org/0000-0003-4829-3626)
- Huan T. Chang
- Sadiq Umar
Institutions
- University of Illinois Chicago (US)
- University of Chicago (US)
- Jesse Brown VA Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1744393
- Citations
- 2
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 48.87
Funders
- National Institutes of Health
- University of Illinois at Urbana-Champaign