Prospective assessment of serum neurofilament light chain in platinum-induced and taxane-induced peripheral neuropathy
Taxanes cause greater and sharper sNfL rises than platinum agents. Age-adjusted sNfL associates with neuropathy severity in platinum-treated patients; however, in most patients it is unable to detect early axonal damage before this is detectable with clinical examination.
Authors
- Melanie Hart (ORCID: https://orcid.org/0000-0002-7396-1916)
- Duncan Smyth (ORCID: https://orcid.org/0000-0002-2457-8611)
- Michael Peter Lunn (ORCID: https://orcid.org/0000-0003-3174-6027)
- Martin Förster (ORCID: https://orcid.org/0000-0003-3876-7269)
- A. Carr
- Miles Chapman
- Stephen Keddie
- Ryan Y S Keh
- Michael Chou
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- MRC Prion Unit (GB)
- UCL Biomedical Research Centre (GB)
- Institute of Neuroimmunology of the Slovak Academy of Sciences (SK)
- CRUK Lung Cancer Centre of Excellence (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- BMJ Neurology Open
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1136/bmjno-2025-001312
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Johns Hopkins University
- University College London
- Neurological Foundation of New Zealand
- University College London Hospitals NHS Foundation Trust