Unilateral Tongue and Lip Edema: A Rare Presentation of Angiotensin-Converting Enzyme (ACE) Inhibitor-Induced Angioedema

Angiotensin-converting enzyme (ACE) inhibitor-induced angioedema is a rare but potentially life-threatening adverse effect that may occur years after treatment initiation. Although it typically presents with bilateral facial or oropharyngeal swelling, unilateral tongue involvement is exceptionally rare and diagnostically challenging. We report the case of a 77-year-old man on long-term ACE inhibitor therapy who presented with sudden unilateral tongue and lip edema. Symptoms improved with supportive treatment and drug discontinuation. This case highlights the importance of recognizing atypical presentations to ensure prompt diagnosis, appropriate management, and improved patient safety.