Targeting the NAT10-HDAC4 positive feedback loop counteracts immunosuppression in breast cancer
Our findings identify a self-reinforcing NAT10/HDAC4 signaling circuit that drives breast cancer progression and immune evasion. Targeting NAT10 represents a promising therapeutic strategy to overcome immunosuppression and improve patient outcomes in breast cancer.
Authors
- Song Gao (ORCID: https://orcid.org/0000-0002-6788-2816)
- Da Pang
- Yijun Chu
- Xi Chen (ORCID: https://orcid.org/0000-0001-9579-279X)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Xin Ma (ORCID: https://orcid.org/0009-0002-7131-4245)
- Y T Gong
- Shengye Jin
- Liuying Zhao
- Jianyu Wang
- Xingda Zhang
- Crystal Song Zhang
- Siyu Liu
- Hao Wu
- Hui Li
- Cheng Qian
- Qin Wang
Institutions
- Emory University (US)
- Harbin Medical University (CN)
- Heilongjiang Academy of Sciences (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s13046-025-03638-7
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 22.24