Population‐based cohort validation and replication reveals limited generalizability of cluster‐based <scp>MASLD</scp> subtypes

The subtyping model demonstrated limited generalizability. Nonetheless, the consistent identification of broad cardiometabolic and liver-specific patterns suggests potential value for risk stratification, pending further validation.

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Publication Details

Journal
Diabetes Obesity and Metabolism
Published
2026-01-07
DOI
https://doi.org/10.1111/dom.70448
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Population‐based cohort validation and replication reveals limited generalizability of cluster‐based MASLD subtypes

Guyu Zeng, Weiwei Xu, Junjie Wu, Junfeng Wang
Diabetes Obesity and Metabolism
Liver Disease Diagnosis and Treatment
article

Population‐based cohort validation and replication reveals limited generalizability of cluster‐based MASLD subtypes

Guyu Zeng, Weiwei Xu, Junjie Wu, Junfeng Wang
article en

Abstract

The subtyping model demonstrated limited generalizability. Nonetheless, the consistent identification of broad cardiometabolic and liver-specific patterns suggests potential value for risk stratification, pending further validation.

Diabetes Obesity and MetabolismVol. 28(4)
Utrecht University (NL), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), University Medical Center Utrecht (NL), Maastricht University (NL), Department of Health (TW)
Good health and well-being
Openalex Percentile: Top 96%
Liver Disease Diagnosis and Treatment
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