Retrospective Analysis Of Changes in Pseudocholinesterase (Butyrylcholinesterase) Values Based On Gender And Year

Aim: Pseudocholinesterase (PChE) serum PChE levels increase over time in different populations, leading to faster metabolism of anesthetic agents, shortening the duration of paralysis and requiring additional doses. This makes the assessment of serum PChE levels an important issue for anesthesia safety. Methods: In this retrospective cross-sectional study, preoperative serum PChE levels of 8.951 patients were examined over a seven-year period. Differences by year, the years between which the differences occurred, gender-related changes, and year-gender interactions were analyzed. Results: The mean serum PChE level in all patients was 10.621 ± 0.24 U/L. Linear regression analysis revealed a mean annual increase of 233.66 U/L across years. Male PChE levels were significantly higher than female PChE levels. The Year × Gender interaction was also found to be significant. Consequently, the rate of increase was found to be faster in males than in females. Furthermore, serum PChE levels were higher in females among individuals over 65 years of age. The highest serum PChE levels were observed in individuals under 15 years of age. Conclusions: Conclusions: Differences between men and women may be due to biological differences related to sex, while the overall increase over time may be due to metabolic changes or environmental factors within the population. Therefore, our results suggest that individual sex and hormonal variations, as well as trends in serum PChE levels across populations, may be critical for anesthesia safety.