Sperm DNA fragmentation and assisted reproduction: an umbrella meta-analysis
Elevated SDF adversely affects ART outcomes, with consistent negative associations in IVF and IUI, a weak effect in ICSI, and a strong link to miscarriage in ICSI. These findings clarify the prognostic role of SDF and emphasize the need for standardized assays and large-scale prospective studies before routine clinical implementation.
Authors
- Yu Fu (ORCID: https://orcid.org/0000-0003-4972-0626)
- Bo Wan (ORCID: https://orcid.org/0000-0002-6724-4718)
- Weiying Lu (ORCID: https://orcid.org/0000-0003-2998-2821)
- Ning Ma (ORCID: https://orcid.org/0000-0001-8570-4266)
- Zhi Zhou
Institutions
- Central South University (CN)
- Haikou City People's Hospital (CN)
- Hainan Medical College Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s40001-025-03801-y
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00