KF/Clinoptilolite nanoparticles promoted green synthesis of new Schiff base using multicomponent reaction of activated acetylenic compounds

KF/Clinoptilolite nanoparticles were used as an effective heterogeneous catalyst for the synthesis of Schiff base derivatives by employing three-component reactions of ninhydrine, 1,3-dicarbonyl compounds, electron-deficient acetylenic compounds and ammonium acetate under solvent-free conditions at room temperature. The present protocol has significant advantages, such as high yields, easy purification, and low environmental impact.