Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits
Senescent atrial cells promote a proinflammatory, proarrhythmic substrate predisposing to AF. Senolytic therapy with fisetin alleviates this phenotype, suggesting a potential strategy to prevent age-related AF.
Authors
- T. Kim
- Lily Zhou (ORCID: https://orcid.org/0000-0002-3064-0864)
- Frank W. Sellke (ORCID: https://orcid.org/0000-0002-8886-801X)
- Shilpa Vijayakumar
- Peter Bronk (ORCID: https://orcid.org/0000-0002-9067-2016)
- Christopher Song (ORCID: https://orcid.org/0000-0001-9293-6970)
- Maxfield M. G. Kelsey (ORCID: https://orcid.org/0000-0002-7666-3447)
- Sade Solola Nussbaum
- Elif Sengun
- Dana C. Price (ORCID: https://orcid.org/0000-0002-2697-7835)
- Federica del Monte (ORCID: https://orcid.org/0000-0001-9506-9665)
- David R. Van Wagoner (ORCID: https://orcid.org/0000-0001-8250-9828)
- John M. Sedivy (ORCID: https://orcid.org/0000-0001-9363-4253)
- Jeanne M. Nerbonne (ORCID: https://orcid.org/0000-0001-8334-8499)
- Nilüfer N. Turan (ORCID: https://orcid.org/0000-0003-0710-1237)
- Bum-Rak Choi
- Karim Roder
- B. Sönmez Uydeş-Doğan
- Anatoli Kabakov
- Jun Feng
- Yichun Lu
- Gideon Koren
- Patrycja Dubielecka-Szczerba
- Eric Mi
Institutions
- Cleveland Clinic (US)
- Medical University of South Carolina (US)
- Washington University in St. Louis (US)
- Brown University (US)
- Rhode Island Hospital (US)
- Washington University Medical Center (US)
- Istanbul University (TR)
Publication Details
- Journal
- Heart Rhythm
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.hrthm.2026.01.007
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 32.84
Funders
- Brown University
- Foundation for Barnes-Jewish Hospital
- National Institutes of Health
- National Center for Research Resources