Front Cover: Photo‐Induced Ultra‐Fast Duplex Invasion Targeting Long‐Range Double‐Stranded DNA Using Artificial Nucleotide (ChemBioChem 1/2026)

This image depicts the mechanism of Photo-induced Duplex Invasion (pDI). The artwork illustrates how a single invading strand, modified with the 3-cyanovinylcarbazole nucleoside (CNVK), targets long double-stranded DNA. Under UV irradiation, this modification enables the strand to rapidly open the DNA helix and cross-link to its target sequence. This visual demonstrates the high efficiency of the pDI strategy for recognizing specific genetic sequences, holding significant potential for applications in biotechnology and genomic engineering. More details can be found in the Research Article by Kenzo Fujimoto and co-workers (DOI: 10.1002/cbic.202500626).