Single-cell RNA sequencing reveals the therapeutic mechanism of Calvatia lilacina in promoting wound healing of anal fistula
Our study objectively demonstrated the pharmacological effects of CLS in promoting the wound healing of anal fistula and investigated its mechanisms in terms of regulating the immune inflammatory process of macrophages increases signal communication with fibroblasts while promoting fibroblast transformation.
Authors
- Tangtang He (ORCID: https://orcid.org/0000-0002-3930-0719)
- Ruoyu Mu (ORCID: https://orcid.org/0000-0002-4703-6807)
- Kewei Wang (ORCID: https://orcid.org/0000-0003-1611-7804)
- Bin Jiang (ORCID: https://orcid.org/0000-0002-4622-9703)
- L. H. Zhu
- Juntong Guo
- Wen Min
- Ruiwen Mo
- Jun Chen
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s13020-025-01293-w
- Citations
- 1
- Primary Topic
- Anorectal Disease Treatments and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 39.15
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Priority Academic Program Development of Jiangsu Higher Education Institutions