Phenotype-specific determinants of health-related quality of life in Crohn’s disease and ulcerative colitis: a multicenter cross-sectional study
In this multicenter cross-sectional cohort, correlates of HRQoL differed between Crohn's disease and ulcerative colitis, and objective inflammatory activity, imaging findings, treatment exposure, and modifiable factors showed domain-specific associations with SIBDQ scores. Because temporality cannot be established, these findings should be interpreted as associations rather than causal effects. Nonetheless, they support integrating FC-3 m and cross-sectional imaging markers into HRQoL-guided treat-to-target decisions in routine care and underscore the need for longitudinal studies to validate these phenotype-specific determinants over time.
Authors
- Osama Hroub (ORCID: https://orcid.org/0009-0006-6889-2932)
- Mohammed F. Saleh (ORCID: https://orcid.org/0000-0002-5216-4897)
- Qusay Abdoh (ORCID: https://orcid.org/0009-0001-4356-8240)
- Haitham Abu Khadija (ORCID: https://orcid.org/0000-0002-2336-3125)
- Abdalaziz Darwish (ORCID: https://orcid.org/0000-0002-3231-3672)
- Mohammad Alnees (ORCID: https://orcid.org/0000-0002-5577-8499)
- Duha Najajra (ORCID: https://orcid.org/0009-0007-3561-2380)
- Nizar Abu Hamdeh (ORCID: https://orcid.org/0009-0000-4209-0137)
- Ali Abdullah (ORCID: https://orcid.org/0009-0007-3696-6076)
- Omar Abu-Khazneh
- Saleem Majadleh (ORCID: https://orcid.org/0009-0009-5771-8463)
- Anwar Zahran
- Yahya Z. Fraitekh
- Jebrin Alkrinawi
- Mohamed Khalil
- Osama Ewidat
- Yara Qassem
- Abed AL Rahman Kabaha
- Omar Y. AbuAlayan
- Mohammad Khader
- Mohammad Maswadeh
- Asseel Daoud
- Mohammad Masu’d
- Mohammed A. Barakat
Institutions
- Hebron University (PS)
- Bethlehem University (PS)
- An-Najah National University (PS)
- Kaplan Medical Center (IL)
- Palestine Polytechnic University (PS)
- Institute for Postgraduate Medical Education (CZ)
- National University Hospital (SG)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1186/s12876-025-04584-6
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00