Fe3O4MNPs promoted green synthesis of 1,3-oxazole derivatives: Study of antimicrobial and antioxidant activity

In this research bio-Fe3O4-MNPs (iron-oxide magnetic nanoparticles) promoted synthesis of 2-thioxo-1,3-oxazole derivatives using multicomponent reaction of α-bromo ketones, alkyl (aryl) isothiocyanates, sodium hydride and catalytic amount of Fe3O4 MNPs in water at room temperature in good yields. Also, Fe3O4-MNPs were generated using Orange peel water extract as green procedure that reduce the ferric chloride solution. The nanoparticles that is generated via biosynthesis method have potentially valuable in different purposes such as organic synthesis. In addition, for study of antioxidant ability of some synthesized thioxo-1,3-oxazoles, diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction testes are employed. Among studied thioxo-1,3-oxazoles, 4b have good power for radical trapping and reduction activity than to standard antioxidant such as BHT and TBHQ. In addition, the antimicrobial activity of some thioxo-1,3-oxazoles was studied employing the disk diffusion test on Gram-positive bacteria and Gram-negative bacteria. The results of disk diffusion test showed that compound 4a, 4b, 4d and 4f prevented the bacterial growth.