Cerebral small vessel disease moderates the association between executive dysfunction and spontaneous neural activity in adults who lost their only child
Executive dysfunction subjects demonstrated abnormal spontaneous activity in SFG and STG. The moderation analysis suggested that CSVD burden may be associated with a greater reduction in executive dysfunction-related frontal hypoactivity, supporting the construction of a "vascular-neuro-cognitive" triad model.
Authors
- Yifeng Luo (ORCID: https://orcid.org/0000-0003-1685-9250)
- Lianli Qiu
- Qi Rongfeng
- Zhuoman Xia
- Zhihong Cao
- Wesley Surento (ORCID: https://orcid.org/0000-0003-0745-1552)
- Feng Chen (ORCID: https://orcid.org/0000-0003-3508-8834)
- Xiang Liu (ORCID: https://orcid.org/0000-0003-3190-4814)
- Li Rita Zhang (ORCID: https://orcid.org/0000-0002-5338-6096)
- Guangming Lu
- Liyan Dai
- Chao Liang
- Ting Li
Institutions
- Jiangsu University (CN)
- Central South University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- University of Washington Medical Center (US)
- Nanjing Drum Tower Hospital (CN)
- Hainan General Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Yixing People's Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Hainan Medical University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- BMC Medical Imaging
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s12880-025-02145-7
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00