Disruption of Bacterial Biofilms by Photothermal Energy to Overcome Antibiotic Resistant Phenotype

Chitosan-modified Au-NR showed enhanced localized heat following exposure to NIR. This led to an enhancement of antibiofilm antibiotic efficacy, significantly decreasing the remaining number of colony-forming bacteria. It is envisioned that this approach could provide the basis for the development of a more effective antibiofilm therapeutic strategy, especially for treating wound infections.