Challenges of monocyte HLA-DR targeted immunomodulation in sepsis—a prospective observational cohort study
Reduced monocyte HLA-DR expression in sepsis reflects broad disruptions across multiple pathways, explaining the limited efficacy of therapeutic interventions. Further insights into the mechanisms governing therapeutic modulation of monocyte HLA-DR and immune function are required to identify patients who are most likely to benefit from intervention.
Authors
- Derek W. Gilroy (ORCID: https://orcid.org/0000-0003-3476-0844)
- Francis Ryckaert
- D Brealey
- Timothy Arthur Chandos Snow (ORCID: https://orcid.org/0000-0002-8395-7857)
- Julia Flint
- Antoine Villa
- Antonio Cesar
- Nishkantha Arulkumaran
- Mervyn Singer
- Naveed Saleem
- Deborah Smyth
- Holly Pan
Institutions
- Bury College (GB)
- UCL Biomedical Research Centre (GB)
- MRC Unit for Lifelong Health and Ageing (GB)
- University College London (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1709289
- Citations
- 1
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 24.43
Funders
- National Institute for Health and Care Research
- University College London
- Intensive Care Society
- Royal College of Anaesthetists
- University College London Hospitals NHS Foundation Trust
- European Society of Intensive Care Medicine
- Medical Research Council