Somatic Drivers in Aldosterone-producing Adenomas and Nodules: Insights from a Brazilian Cohort of Primary Aldosteronism
We confirmed the predominance of known somatic drivers and identified a uniquely high frequency of ATP2B3 variants, refining their clinical phenotype. These findings underscore the influence of population-specific genetic backgrounds and expand the global understanding of PA genetics.
Authors
- Augusto G Guimarães
- Giovânio Silva
- Luiz Aparecido Bortolotto (ORCID: https://orcid.org/0000-0002-4865-6442)
- Felipe L Ledesma (ORCID: https://orcid.org/0000-0001-7857-7318)
- Luciano F. Drager (ORCID: https://orcid.org/0000-0002-2081-6846)
- Tatiana S Goldbaum
- Victor Srougi (ORCID: https://orcid.org/0000-0001-8346-3833)
- W C Nahas
- Fábio Y Tanno (ORCID: https://orcid.org/0000-0001-9148-8002)
- Lucas Barbosa Rossetti
- Eduardo Z Kawahara (ORCID: https://orcid.org/0009-0002-8054-2098)
- Ana Claudia Latronico
- Jessica Okubo (ORCID: https://orcid.org/0000-0002-2519-5073)
- Lucas Silva Santana
- Madson Quriroz Almeida
- Berenice Bilharinho Mendonca
- Jose Antonio B L Sobrinho
- Felipe Freitas-Castro
- Maria Claudia N Zerbini
- Maria Adelaide A Pereira
- Maria Candida B V Fragoso
- Jose L Chambo
- Andrea Pio-Abreu
Institutions
- Instituto do Câncer do Estado de São Paulo (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Instituto do Coração (PT)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1210/clinem/dgag002
- Citations
- 1
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 30.73