Levodopa Suppresses Choroidal Neovascularization Through a Tyrosinase-Dependent Dual Mechanism
Our findings show that L-DOPA's anti-angiogenic effects are exogenous, more effective in tyrosinase-mutant mice, and mediated by both the DRD2 and non-DRD2 pathways, potentially GPR143. The saturation of GPR143 signaling in pigmented eyes provides a mechanistic basis for reduced responsiveness, highlighting the importance of pigmentation biology in the development of L-DOPA-based therapeutics.
Authors
- Jeremy A. Lavine (ORCID: https://orcid.org/0000-0002-0884-1336)
- Amrita Rajesh
- Joyce Gong
- Induvahi Veernala
- Andrea Sara Cuamatzi-Castelan
- Godlyn J. D'Souza
Institutions
- Northwestern University (US)
- Twitter (United States) (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1167/iovs.67.1.8
- Citations
- 1
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 23.07
Funders
- Research to Prevent Blindness
- Northwestern University
- National Institutes of Health
- Genentech
- Robert H. Lurie Comprehensive Cancer Center