Guaianolide dimer KGA-1002 targets GRP94 and triggers unfolded protein response-associated degradation of SKP2/AKT axis as a novel antihepatoma agent
KGA-1002 was identified as a highly promising lead compound for antiHCC. Its mechanism involved triggering UPR-associated degradation and disrupting the GRP94-AKT interaction. KGA-1002 simultaneously induced apoptosis and ferroptosis in HCC cells through the GRP94/AKT/SKP2/P21 signaling axis.
Authors
- Qi-Hao Li
- Feng-Dan Huang
- Fengjiao Li (ORCID: https://orcid.org/0009-0009-1444-8600)
- Minmin Hu
- Yanru Wang (ORCID: https://orcid.org/0000-0001-8272-2450)
- Xiao-Yan Huang
- Tian-Ze Li
- Ji-Jun Chen
- Wen-Jing Ma
Institutions
- Kunming Institute of Botany (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.jare.2026.01.010
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00