Muscle MRI Contributes to the Differential Diagnosis Between Distal Myopathies and Distal Hereditary Motor Neuropathies
Analysis of MRI features can help distinguish between DMs and dHMNs. A reticular pattern is an early feature of dHMNs while muscle islands are identified in advanced stages and in some forms of DMs, though not specific to neurogenic conditions. We recommend including foot muscles in the MRI protocol as they show extensive involvement in most dHMNs, while in DMs their involvement correlates with greater fatty infiltration of lower leg muscles.
Authors
- María José Tarrega
- Sofía Portela
- Teresa Sevilla (ORCID: https://orcid.org/0000-0003-4716-2667)
- Inmaculada Palazón Azorín
- Herminia Argente‐Escrig (ORCID: https://orcid.org/0000-0001-8537-1318)
- Nuria Muelas (ORCID: https://orcid.org/0000-0002-2349-7481)
- Juan F. Vázquez‐Costa (ORCID: https://orcid.org/0000-0002-3043-7938)
- María Payá
- Karolina Aragon‐Gawinska (ORCID: https://orcid.org/0000-0002-6447-6388)
- Juan José Gallego Vílchez
- Roger Vílchez
- Rafael Sivera
- Pilar Martí
- Fernando Más‐Estellés
- Marina Frasquet
Institutions
- Universitat de València (ES)
- Universidad Cardenal Herrera CEU (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Centro de Investigación Biomédica en Red (ES)
- ERN GUARD-Heart (NL)
- Instituto de Investigación Sanitaria La Fe (ES)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1111/ene.70456
- Citations
- 1
- Primary Topic
- Hereditary Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 23.21
Funders
- Rare Diseases Clinical Research Network
- European Commission
- Instituto de Salud Carlos III