NDUFS4, a mitochondrial complex I subunit, is essential for T-cell metabolic fitness and immune function
These findings highlight the importance of NDUFS4 for human immunity and establish a mechanistic link between complex I dysfunction and T-cell immunodeficiency. Our results identify NDUFS4 as a key regulator connecting mitochondrial integrity to adaptive immune function.
Authors
- Or Reuven (ORCID: https://orcid.org/0000-0001-6443-8181)
- Yuval Tal (ORCID: https://orcid.org/0000-0002-3633-2520)
- Amijai Saragovi (ORCID: https://orcid.org/0000-0002-4376-1390)
- Atar Lev (ORCID: https://orcid.org/0000-0003-3416-1243)
- Zahala Bar-On
- Hagar Mor-Shaked
- Wajeeh Salaymeh
- Michael Berger
- Oded Shamriz
- Raz Somech
- Aviva Fattal-Valevski
- Leonor Cohen-Daniel
- Ayelet Sheer
- Omri Yosef
- Simon Edvardson
Institutions
- Tel Aviv University (IL)
- Hebrew University of Jerusalem (IL)
- University of Washington (US)
- Tel Aviv Sourasky Medical Center (IL)
- Hadassah Medical Center (IL)
- Concern Foundation (US)
- Edmond and Lily Safra Children's Hospital (IL)
- Protein Research Foundation (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1734203
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00