Differences in T-cell counts and neighborhood patterns in human colorectal adenomas and sessile serrated lesions

TVs are characterized by lower T-cell infiltration and a greater tendency for regulatory T-cell clustering, consistent with an immune-cold TiME relative to TAs. SSLs and TAs were both more immune-infiltrated than TVs, but SSLs appeared less inflamed and less dominated by regulatory subsets. In contrast, CD4⁺dominant clustering in TAs suggested stronger helper coordination. Preinvasive lesions therefore demonstrate immune and spatial heterogeneity by lesion types.

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Publication Details

Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2026-01-06
DOI
https://doi.org/10.64898/2026.01.06.697786
Primary Topic
Colorectal Cancer Screening and Detection
Type
article
Field-Weighted Citation Impact
0.00

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article

Differences in T-cell counts and neighborhood patterns in human colorectal adenomas and sessile serrated lesions

Alexander V. Alekseyenko, Todd A. MacKenzie, David Lewin, John A. Baron et al.
bioRxiv (Cold Spring Harbor Laboratory)
Colorectal Cancer Screening and Detection
article

Differences in T-cell counts and neighborhood patterns in human colorectal adenomas and sessile serrated lesions

Alexander V. Alekseyenko, Todd A. MacKenzie, David Lewin, John A. Baron, Kristin Wallace, Souvik Seal, Martha J. Shrubsole, Lauren R. Fanning, Dale C. Snover, Antonis Kourtidis, Christine Bookhout, Silvia Guglietta, Evan Bagley, Elizabeth L.R. Barry, Elizabeth O'Quinn
article en

Abstract

TVs are characterized by lower T-cell infiltration and a greater tendency for regulatory T-cell clustering, consistent with an immune-cold TiME relative to TAs. SSLs and TAs were both more immune-infiltrated than TVs, but SSLs appeared less inflamed and less dominated by regulatory subsets. In contrast, CD4⁺dominant clustering in TAs suggested stronger helper coordination. Preinvasive lesions therefore demonstrate immune and spatial heterogeneity by lesion types.

bioRxiv (Cold Spring Harbor Laboratory)
Dartmouth College (US), University of North Carolina at Chapel Hill (US), Medical University of South Carolina (US), Vanderbilt University (US), MUSC Hollings Cancer Center (US), Fairview Southdale Hospital (US), Vanderbilt-Ingram Cancer Center
University of South Carolina, Hollings Cancer Center, Medical University of South Carolina, National Cancer Institute
Openalex Percentile: Top 96%
Colorectal Cancer Screening and Detection
DOIOpen Access PDFOpenAlex
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