5-hydroxyeicosatetraenoic acid and 12-hydroxyeicosapentaenoic acid regulate basophil and mast cell activation and basophil recruitment in chronic spontaneous urticaria
In conclusion, 5-HETE and 12-HEPE may regulate IgE-mediated activation of MCs and basophils and recruitment of basophils in the CSU, respectively, suggesting that these LMs may be involved in the enlargement of wheal reactions.
Authors
- Mana Ito
- Yoshimi Miki (ORCID: https://orcid.org/0000-0002-8587-0333)
- Koremasa Hayama (ORCID: https://orcid.org/0000-0001-8651-2493)
- Makoto Murakami
- Yoshitaka Taketomi (ORCID: https://orcid.org/0000-0003-4094-9846)
- Maho Tagui (ORCID: https://orcid.org/0000-0001-8152-6802)
- Yoshimichi Okayama (ORCID: https://orcid.org/0000-0001-5469-3541)
- Hideki Fujita
- Shota Toyoshima
Institutions
- Nihon University (JP)
- Tokyo Medical University (JP)
- University of Tokyo Hospital (JP)
- Tokushima University (JP)
Publication Details
- Journal
- Allergology International
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.alit.2025.12.005
- Primary Topic
- Urticaria and Related Conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00