Safety, Feasibility, and Preliminary Efficacy of Allogeneic MSCs to Treat Advanced Femoral Head Osteonecrosis (ALOFEM): A Pilot Study in Young Onco‐Hematological Patients
The implantation of expanded allogeneic MSC in young patients to prevent conversion to a THR or collapse of the femoral head due to severe osteonecrosis is feasible without safety concerns in the longer-term follow-up (FU) upto 4 years. <b>Trial Registration:</b> EudraCT number: 2018-000886-35.
Authors
- Trinidad Martín-Donaire
- E. Gómez-Barrena
- Rocío Zafra
- Yasmina Mozo (ORCID: https://orcid.org/0000-0002-5666-1911)
- María Esther Martínez-Muñoz (ORCID: https://orcid.org/0000-0002-6829-9710)
- Rafael Duarte (ORCID: https://orcid.org/0000-0001-9657-8429)
- Jose Juan Pozo-Kreilinger
- Cristina Avendaño-Solà
- Juan Cabello-Blanco
- Norma G. Padilla-Eguiluz
- Ana Velasco-Iglesias
- Concepción Payares-Herrera
Institutions
- Hospital Universitario La Paz (ES)
- Hospital La Paz Institute for Health Research (ES)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Stem Cells International
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1155/sci/1986839
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III