Independent, but not synergistic, associations of <i>APOE</i> ε4 and systemic inflammation on cognitive decline: findings from the Women’s Health Initiative
In this large longitudinal study of post-menopausal women, our findings support the hypothesis that genetic risk and systemic inflammation independently influence cognitive decline, but there was no evidence of synergistic effects in postmenopausal women. Further research is needed to elucidate the mechanistic pathways underlying these associations with cognitive decline.
Authors
- Su Yon Jung (ORCID: https://orcid.org/0000-0002-0513-1830)
- Rachel F. Buckley (ORCID: https://orcid.org/0000-0002-5356-5537)
- Ramon Casanova (ORCID: https://orcid.org/0000-0002-6934-5942)
- Stephen R. Rapp (ORCID: https://orcid.org/0000-0002-9766-3104)
- Suzanne L. Baker (ORCID: https://orcid.org/0000-0003-0209-3127)
- Gillian Coughlan (ORCID: https://orcid.org/0000-0003-1806-702X)
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- Hannah M Klinger
- J E Manson
- Aladdin H. Shadyab
- Simin Liu
- Susan M. Schembre
- Robert A. Wild
- Jean Wactawski-Wende
- Longjian Liu
- Kathleen M. Hayden
- Susan M. Resnick
- Dorene M. Rentz
Institutions
- National Institutes of Health (US)
- Harvard University (US)
- Lawrence Berkeley National Laboratory (US)
- The University of Melbourne (AU)
- John Brown University (US)
- Georgetown University (US)
- University of California System (US)
- University of California San Diego (US)
- Wake Forest University (US)
- University of Oklahoma Health Sciences Center (US)
- University at Buffalo, State University of New York (US)
- Drexel University (US)
Publication Details
- Journal
- Journal of Clinical and Experimental Neuropsychology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1080/13803395.2025.2608340
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00