Identification of multiple cardiotonic steroids in faecal material of untreated humans and rat strains
Multiple CTSs were detected in faecal material of untreated rats and humans. Steroids varied between rat strains and aligned with phenotype. Extraction requires further solvent optimisation and the use of tandem MS/MS is essential to reliably detect the profile of CTSs present. Analysis of CTSs present in readily available faecal material will enable studies to determine relationships between CTSs, the microbiome and disease progression.
Authors
- S. Dinat (ORCID: https://orcid.org/0000-0002-4040-6828)
- Zelie Flavienne Masso
- Anza Thiba
- A D Cromarty
- Angela J. Woodiwiss (ORCID: https://orcid.org/0000-0003-2555-4125)
- Geoffrey Candy (ORCID: https://orcid.org/0000-0002-5449-1277)
- Ekene E. Nweke supervisor
- Gavin R. Norton
- Hannah Bint Ebrahim Mullah
Institutions
- University of the Witwatersrand (ZA)
- University of Pretoria (ZA)
Publication Details
- Journal
- Steroids
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1016/j.steroids.2026.109747
- Primary Topic
- Steroid Chemistry and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00