Molecular, Transcriptomic, and Proteomic Characterization of <i>Plasmodium</i> Infections that Evade Detection by Rapid Diagnostic Tests in Mizan Aman, Ethiopia

Our molecular, transcriptomic, and proteomic characterization of <i>P. falciparum</i> infections that fail detection by PfHRP2/pLDH-based RDTs in Mizan Aman, Ethiopia, revealed a heterogeneous array of factors that could be responsible for the observed RDT failure.

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Publication Details

Journal
medRxiv
Published
2026-01-06
DOI
https://doi.org/10.64898/2026.01.04.25343089
Primary Topic
Malaria Research and Control
Type
article
Field-Weighted Citation Impact
0.00
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article

Molecular, Transcriptomic, and Proteomic Characterization of Plasmodium Infections that Evade Detection by Rapid Diagnostic Tests in Mizan Aman, Ethiopia

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Molecular, Transcriptomic, and Proteomic Characterization of Plasmodium Infections that Evade Detection by Rapid Diagnostic Tests in Mizan Aman, Ethiopia

Z Wang, Jane M. Carlton, Maria Nikulkova, Harsh Srivastava, Taye Teka, Daniel Tesfaye, Guiyun Yan, Biniam Lukas, Anne Kessler, Abhishek Patel, Delenasaw Yewhalaw, Tirusew Tolessa, Marta Zemede, Fikirte Legesse, Steven A. Sullivan, Deje Lemessa
article en

Abstract

Our molecular, transcriptomic, and proteomic characterization of <i>P. falciparum</i> infections that fail detection by PfHRP2/pLDH-based RDTs in Mizan Aman, Ethiopia, revealed a heterogeneous array of factors that could be responsible for the observed RDT failure.

medRxiv
Jimma University (ET), Johns Hopkins University (US), University of California, Irvine (US), New York University (US)
Good health and well-being
Openalex Percentile: Top 96%
Malaria Research and Control
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