Beyond the Skin: Topical Amphotericin B Nanocarriers Targeting Cutaneous Leishmaniasis with Suppression of Lymphatic Parasite Burden
PCL-AmB and Oil_AmB reduced lesions and parasite burden in <i>L. amazonensis</i>-infected mice. Treatment timing was critical, with early Oil_AmB also reducing parasite loads in draining lymph nodes. These findings suggest that topical AmB formulations may provide a promising alternative for CL treatment, though further studies are required to optimize efficacy and administration schedules.
Authors
- Beatriz Ferreira de Carvalho Patricio (ORCID: https://orcid.org/0000-0002-2477-9798)
- Gabriel Lima Barcellos
- Luzia Monteiro de Castro Côrtes (ORCID: https://orcid.org/0000-0003-3614-8763)
- Juliana Figueiredo Peixoto
- Francisco Alexandrino-Júnior (ORCID: https://orcid.org/0000-0002-1173-9164)
- Luiz Filipe Gonçalves-Oliveira (ORCID: https://orcid.org/0000-0001-7770-1962)
- Helvécio Vinícius Antunes Rocha
- Carlos Roberto Alves
- Franklin Souza-Silva
- Geovane Dias-Lopes
Institutions
- Universidade do Estado do Rio de Janeiro (BR)
- Universidade Iguaçu (BR)
- Universidade Católica de Petrópolis (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- Infectious Disease Reports
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3390/idr18010006
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação Oswaldo Cruz