Molecular characterization of cell decay in inflammation and topological assignment of released cfDNA for integrative laboratory and radiological outcome assessment
Implementing the cfDNA integrity index on an automated gel electrophoresis demonstrated promising results in predicting clinical outcomes like ARDS occurrence and mortality. Therefore, integrating laboratory and imaging resources could enhance the allocation of optimal care and may identify secondary systemic complications, especially liver involvement, as our results suggest reduced lead-time for detecting liver injury.
Authors
- Jörg Krebs
- Christoph Fischer (ORCID: https://orcid.org/0000-0002-7202-148X)
- Stefanie Nittka (ORCID: https://orcid.org/0000-0003-2081-5760)
- Catharina Gerhards (ORCID: https://orcid.org/0000-0001-7197-9242)
- Alexander Hertel (ORCID: https://orcid.org/0000-0002-5438-1887)
- S Schoenberg
- Michael Neumaier (ORCID: https://orcid.org/0000-0003-0136-3754)
- Marlis Gerigk
- Maren Hedtke
- Jürgen Hench
- Matthias F. Froelich
- Volker Ast
- Andreas Teufel
- Osman Evliyaoglu
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Hospital of Basel (CH)
- Institute of Medical Microbiology and Hygiene (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fcimb.2025.1720862
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00