Inter-individual differentially methylated region-targeted EWAS reveals epigenetic signatures of early childhood adversity
Our findings suggest that early adversity may contribute to lasting epigenetic modifications in children. The identified DMRs may serve as noninvasive biomarkers for retrospective ACE assessment and provide insights into the biological embedding of early-life stress.
Authors
- Jun Ito (ORCID: https://orcid.org/0009-0002-5298-9829)
- Shiori Minabe (ORCID: https://orcid.org/0000-0001-7902-925X)
- Takehito Yanbe
- Kanako ONO
- Atsushi Shimizu (ORCID: https://orcid.org/0000-0002-7306-7412)
- Shusaku Chiba (ORCID: https://orcid.org/0000-0002-0407-0773)
- Taira Mayanagi
- Kenji Sobue
- Manami Akasaka (ORCID: https://orcid.org/0000-0001-7430-3942)
- Junko Yagi
- Yasuhito Yoshioka
- Hideki Ohmomo (ORCID: https://orcid.org/0000-0002-3524-6524)
- Chiho Ishikawa
- Mare Uchide
- Nozomi Kaneko
- Shohei Komaki (ORCID: https://orcid.org/0000-0002-0486-3239)
- Kaori Ogawa
- Kentaro Fukumoto
Institutions
- Iwate Medical University (JP)
Publication Details
- Journal
- Epigenomics
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1080/17501911.2026.2613008
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 22.24