Protective effects of traditional Chinese medicines Aconiti Lateralis Radix Praeparata and Angelicae Sinensis on H/R cardiomyocytes via the PI3K/Akt/GSK-3β pathway and autophagy pathway

This study demonstrated that the combination of Aconiti Lateralis Radix Praeparata and Angelicae Sinensis significantly protected H/R cardiomyocytes in vitro. This protective effect was achieved through enhancing cell viability, reducing oxidative stress-induced injury, and modulating the expression and distribution of key proteins and genes. The underlying mechanisms involved the activation of the PI3K/Akt/GSK-3β signaling pathway and the autophagy pathway, as confirmed by the inhibitory effect of LY294002.