Magnesium degradation-induced variable fixation plates promote the vascularization of femoral fracture in rabbits
MVFP's variable fixation, which initially provides stability and then transitions to micro-motion, more effectively promotes angiogenesis at the fracture site compared to the rigid LP and AMLP fixation methods, facilitating fracture healing. MVFP may enhance angiogenesis through the JAK-STAT, VEGF, and PI3K-Akt signaling pathways.
Authors
- Xieping Dong (ORCID: https://orcid.org/0000-0001-6919-151X)
- Jian Wen (ORCID: https://orcid.org/0000-0002-6370-3964)
- Xinyu Wang (ORCID: https://orcid.org/0000-0003-0806-4335)
- Xiaofan Chen (ORCID: https://orcid.org/0000-0002-4508-5971)
- Xueqi Liu
- Yu Zeng
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Integrated Chinese Medicine (China) (HK)
- Jiangxi Provincial People's Hospital (CN)
- Ningxia Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s13018-025-06528-y
- Citations
- 1
- Primary Topic
- Magnesium Alloys: Properties and Applications
- Type
- article
- Field-Weighted Citation Impact
- 22.64