Assessment of Corvis ST biomechanical parameters in diagnosing primary open-angle glaucoma in high myopia

Abstract: PURPOSE: The purpose of this study was to investigate the diagnostic value of the Corvis ST parameters in primary open-angle glaucoma (POAG) among high myopes. METHODS: A total of 49 eyes (33 POAG cases and 16 controls) of 49 high myopes (axial length ≥26 mm) from open online datasets were analyzed. The Corvis ST parameters were compared between the POAG and the control eyes after adjusting for age and sex. Logistic regression models were used to analyze the associations between POAG and each Corvis ST parameter, with adjustments for age and sex. The receiver operating characteristic (ROC) curves were used to assess the diagnostic value of the significant parameters in the logistic models. The linear support vector machine (SVM) model was fitted using parameters demonstrating diagnostic values in the ROC analyses. RESULTS: The means of the following biomechanical parameters were significantly lower in patients with POAG: A1 time ( P = 0.004), A1 length ( P = 0.011), A2 length ( P = 0.035) and peak distance (PD, P < 0.001). Conversely, the mean A1 velocity (P < 0.001) and concavity curvature radius ( P = 0.035) were significantly higher in eyes with POAG. In the logistic regression models, POAG was significantly associated with the A1 time ( P = 0.014), A1 velocity ( P = 0.003), A1 length ( P = 0.043), and PD ( P = 0.004). The ROC analyses demonstrated diagnostic utility for A1 time (area under the curve [AUC]: 0.77), A1 velocity (AUC: 0.78), and PD (AUC: 0.87). In the SVM model, the model demonstrated good performance, with a classification accuracy of 0.898. CONCLUSION: In high myopia patients, Corvis ST parameters, including A1 time and PD, demonstrated a potential diagnostic value for POAG.